Peninsula Manila is located in Makati City, Manila's business district. Guests of the hotel will find many places of interest nearby, including upscale shops, fine dining, the Philippine International Convention Center, the Manila American Cemetery and Memorial, the Cultural Center for the Philippines, Greenbelt Park, the Ayala Center, and the Santa Ana Racetrack. Peninsula Manila is located near the airport, and offers a shuttle service to and from the terminal. The staff is happy to direct guests to public transportation, or to help arrange taxi or rental car services. Many places of interest are within walking distance from the hotel.

There are 498 guest rooms and suites at Peninsula Manila, each equipped with satellite televisions, mini bars, refrigerators, en suite baths, hair dryers, complimentary toiletries, telephones, Internet connections, clock radios, work desks, coffee and tea machines, and premium bedding and linens.

This hotel is a luxury accommodation, offering guests amenities such as a swimming pool, a well-equipped fitness center, spa facilities, business and meeting spaces, ballrooms, numerous restaurants, cocktail lounges, and cafes. Peninsula Manila staff is happy to help arrange laundry, safe deposit, and child care services.